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Systems Biology: A Short Overview

Predicting the outcome of an observable phenomenon belongs to the key disciplines of natural sciences. A chemist can precisely calculate the temperature increase when dehydrating sugars upon contact with sulfuric acid. A physicist can predict the force needed to leverage a rock of a certain weight. But for a biologist, the situation is different. It is an excessively difficult and time-consuming task to perform detailed calculations on biological systems. For a long time, it was even believed that a mysterious vital spark drives all living entities. So what makes calculations in biology so different from other sciences? Living entities belong to the most complex systems in existence. At the most basic level, a single cell comprises huge numbers of molecules and is structured in a very de...

published: 11 Sep 2016
Systems Biology Explained

Dr. Nathan Price, ISB's Associate Director, shares his explanation of systems biology and why the systems approach is necessary and inevitable. Systems biology is a holistic approach that involves biology, technology and computation. ISB in Seattle is the home of systems biology.

published: 06 Apr 2013
What is Systems Biology

Dr. Nitin Baliga, Director for Integrative Biology at Institute for Systems Biology, explains systems biology.

published: 04 Sep 2012
1. Introduction to Computational and Systems Biology

MIT 7.91J Foundations of Computational and Systems Biology, Spring 2014 View the complete course: http://ocw.mit.edu/7-91JS14 Instructor: Christopher Burge, David Gifford, Ernest Fraenkel In this lecture, Professors Burge, Gifford, and Fraenkel give an historical overview of the field of computational and systems biology, as well as outline the material they plan to cover throughout the semester. License: Creative Commons BY-NC-SA More information at http://ocw.mit.edu/terms More courses at http://ocw.mit.edu

published: 20 Jan 2015
Systems Biology and Intelligent Design

What light does systems biology shed on the intelligent design of living things in nature? Biologist Emily Reeves explores how systems biology helps us better understand the intelligent design of nature. This presentation was taped at the 2022 Westminster Conference on Science and Faith in the greater Philadelphia area, which was jointly sponsored by Discovery Institute's Center for Science and Culture and Westminster Theological Seminary. Dr. Emily Reeves is a scientist with the Center for Science and Culture at Discovery Institute. She is a biochemist, metabolic nutritionist, and aspiring systems biologist. Her doctoral studies were completed at Texas A&M; University in Biochemistry and Biophysics. ============================ The Discovery Science News Channel is the official Youtube c...

published: 11 Oct 2022
Human Body Systems Functions Overview: The 11 Champions (Older Video 2016)

This is the 2016 (older) Amoeba Sisters human organ systems video, which provides a brief function introduction to each of the 11 human organ systems. Video has been updated (2024) here! https://youtu.be/0JDCViWGn-0 Expand details for table of contents.👇 Video has handout: http://www.amoebasisters.com/handouts Note: This overview provides the name of each organ system and overall body system functions. This can support further discussion on how these functions work together. While structure detail is not included in this brief overview, this can provide a foundation for further exploration of body system structures. If interested in some more detail on a particular body system, we've been creating videos on one body system at a time! Visit our playlist here: https://www.youtube.com/play...

published: 24 Apr 2016
Systems Biology: Where Computer Science, Engineering and Biology Meet

During the last decade an entirely new approach to studying biology has emerged from the collaboration of traditional biologists with those trained in other fields. New measurement techniques are used to observe thousands of properties of cells, and algorithmic approaches are applied to assemble these data into a coherent picture of how cells function in particular conditions. These methods are beginning to reveal previously unrecognized cellular pathways that could be targeted to treat diseases.

published: 21 Dec 2012
Computer-Simulation of Biological Systems

Computer simulations of metabolic models and genetic regulation are becoming increasingly popular. The video introduces fundamental concepts and describes a selection of frequently used software solutions for creating pathway maps, access of genome-scale models, simulation and analysis of these models. The file format SBML facilitates interoperability between these tools. This work has been conducted in a collaboration between UC San Diego and the University of Tuebingen within the EU project AMBiCon. For more information see http://systems-biology.info.

published: 27 Sep 2016
Systems biology course 2018 Uri Alon - Lecture 1 - Basic concepts

Lecture 1 - Basic concepts

published: 13 May 2018

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Systems Biology: A Short Overview

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Duration: 2:58
Uploaded Date: 11 Sep 2016
views: 62618

Predicting the outcome of an observable phenomenon belongs to the key disciplines of natural sciences. A chemist can precisely calculate the temperature increase when dehydrating sugars upon contact with sulfuric acid. A physicist can predict the force needed to leverage a rock of a certain weight. But for a biologist, the situation is different. It is an excessively difficult and time-consuming task to perform detailed calculations on biological systems. For a long time, it was even believed that a mysterious vital spark drives all living entities. So what makes calculations in biology so different from other sciences? Living entities belong to the most complex systems in existence. At the most basic level, a single cell comprises huge numbers of molecules and is structured in a very densely organized space, All those molecules participate in a numerous biochemical reactions, highly regulated enzymes drive these reactions, and external signals interfere with the cell, in the form of hormones, drugs, or variations in the amount of nutrition available. It is not possible for the human mind to keep track of so many processes in parallel. So, how can we calculate effects of cellular functions? The most viable option is to construct highly detailed computer models that facilitate visualization and statistics to see trends, and mathematical modeling to precisely calculate interactions of components to predict system behavior. In order to be reliable and diagnostically conclusive, these models need to be constricted to real-world conditions by incorporating physicochemical constraints. However, the complexity of the interactions can still be overwhelming. Yet, making biological phenomena predictable is worthwhile. By simulating entire cellular systems we could: Gain a better understanding of the system in its entirety. Calculate how much medicine a patient should take in order to avoid adverse effects, or Determine potential weaknesses of harmful pathogens as a precursor for drug development. To this end, the University of Tuebingen and the University of California, San Diego, established a joint project with the aim of developing new computational methods that make it possible to model all levels of biological systems. As the result, a wide range of software and database solutions have been created that make building and analyzing systems biology models much more straightforward. For more information, or to download and try systems biology software, visit http://systems-biology.info.

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